DESCRIPTION

Background:

The Wnt signal transduction is essential for cell proliferation and differentiation and the self-renewal of stem cells. Wnt ligands heterodimerize Frizzled (Fz) family receptors and their co-receptors Lrp5/6, triggering downstream signaling pathways including the canonical β-catenin cascade, and resulting in expression of genes regulating cell fate determination. is a 59.6kDa protein that dimerizes Fz and Lrp5/6 and activates canonical Wnt/β-Catenin signaling. Recombinant Wnt/β-Catenin Ligand potently supports different types of organoid growth, including hepatocyte, cholangiocyte, alveoli, breast, colon, pancreas, esophagus and ovarian.